tert-butyl N-[(2R)-2-aMinopropyl]carbaMate

tert-butyl N-[(2R)-2-aMinopropyl]carbaMate - Names and Identifiers

Name	(R)-1-N-Boc-Propane-1,2-diaMine hydrochloride
Synonyms	-tert-Butyl (2-aminopropyl) R-1-n-boc-propane-1,2-diaMine R-1-N-BOC-propane-1,2-diamine-HCl (R)-tert-butyl 2-aminopropylcarbamate tert-Butyl ((R)-2-aminopropyl)carbamate tert-butyl N-[(2R)-2-aMinopropyl]carbaMate (R)-1-N-Boc-Propane-1,2-diaMine hydrochloride ((R)-2-Aminopropyl)carbamic acid tert-butyl ester [(R)-2-Amino-1-propyl]carbamic acid tert-butyl ester Carbamic acid, [(2R)-2-aminopropyl]-, 1,1-dimethylethyl ester (9CI)
CAS	333743-54-7

tert-butyl N-[(2R)-2-aMinopropyl]carbaMate - Physico-chemical Properties

Molecular Formula	C8H18N2O2
Molar Mass	174.24
Density	0.984
Boling Point	264℃
Flash Point	113℃
pKa	12.51±0.46(Predicted)
Storage Condition	Keep in dark place,Inert atmosphere,Room temperature

tert-butyl N-[(2R)-2-aMinopropyl]carbaMate - Introduction

(R)-1-N-Boc-Propane-1,2-diaMine hydrochloride is a compound whose chemical name is (R)-1-N-Boc-Propane-1,2-diaMine hydrochloride. The following is a description of the properties, uses, preparation and safety information of this compound:

Nature:
-Appearance: White crystalline powder
-Molecular formula: C8H19ClN2O2
-Molecular weight: 202.7g/mol
-Melting Point: 165-170 ° C
-Solubility: Soluble in water and some polar solvents

Use:
(R)-1-N-Boc-Propane-1,2-diaMine hydrochloride is a commonly used organic synthesis reagent, mainly used in the synthesis of other compounds. It is usually used as a protective group to protect the amine function from damage in chemical reactions. In addition, it can also be used in pharmaceutical research, such as the synthesis of new drugs and drug precursors.

Method:
The preparation of (R)-1-N-Boc-Propane-1,2-diaMine hydrochloride is usually carried out by the following steps:
1. First, (R)-1-hydroxy-2-chloropropane is reacted with tetrahydrofuran to produce (R)-1-hydroxy-2-chloropropyl methyl ether.
2. Then, the methyl ether is reacted with dipropylacetamide and potassium carbonate in the presence of sodium bicarbonate to produce (R)-1-propanediamine.
3. Finally, (R)-1-propanediamine is reacted with BOC acid to form (R)-1-N-Boc-Propane-1,2-diaMine hydrochloride.

Safety Information:
(R)-1-N-Boc-Propane-1,2-diaMine hydrochloride is a chemical, and the following safety precautions should be paid attention to when using:
-Avoid direct contact with skin and eyes, and wear protective gloves and goggles when using.
-Avoid inhaling dust or gas during operation, and ensure that the operation is carried out under well-ventilated laboratory conditions.
-Keep dry and sealed during storage, away from fire and oxidizing agents.
-If accidentally touched or swallowed, rinse immediately with plenty of water and seek medical help.
-During use, local safety operation codes and regulations should be observed.

Last Update：2024-04-09 21:01:54